Steroids Pirfenidone Powder Anti Fibrosis Piresupa CAS 53179-13-8 99% Purity

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High Quality USP Grade SARM Steroids Pirfenidone Powder Anti Fibrosis Piresupa CAS:53179-13-8

 

Basic info.

 

Product Name: Pirfenidone

CAS: 53179-13-8
MF: C12H11NO
MW: 185.22
Appearance: A little yellow to white powder

Purity: 99.70%

Shelf life: 3 years

Standard: Enterprise standard

Usage: Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver.

 

COA:

 

ItemStandard
AppearanceWhite crystal powder
Melting Point102--109째C
Loss on drying<1.0%
Known single impurity<1.0%
Unknown single impurity<0.5%
Total impurity<2.0%
Assay(as dried)99%

 

Product Description:

 

In vitro, pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation. Pirfenidone can inhibit the TGF - beta - 1 inducing fibroblast collagen formation. Inhibition of PDGF, FGF and TGF - beta - 1 inducing fibroblast proliferation. In hamster model, pirfenidone, taken by mouth, that can the prevention and treatment of pulmonary fibrosis induced by bleomycin. Pirfenidone can prevent the sclerosing peritonitis in rats induced by chemical, can also be keloid grafting for the treatment of nude mice.

 

Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also. Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

 

Product Applications:

 

Pirfenidone has demonstrated activity in multiple fibrotic conditions, including those of the lung, kidney and liver.Biological Activity Antifibrotic agent, effective in models of pulmonary and lung fibrosis. Inhibits collagen production and fibroblast proliferation. Regulates cytokine levels following oral administration in vivo . Potent scavenger of free radicals and inhibitor of lipid peroxidation.